Otx2^tm11Asim
Targeted Allele Detail

Summary

• Symbol: Otx2^tm11Asim
• Name: orthodenticle homeobox 2; targeted mutation 11, Antonio Simeone
• MGI ID: MGI:4365830
• Synonyms: Otx2^GFP
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm11Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153562
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The coding region and 3'UTR were replaced with a GFP gene and floxed neo cassette. (J:153562)

Expression

In Mice Carrying this Mutation:	97 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:153562 Acampora D, et al., Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
• All: 8 reference(s)