Pkd1^tm2.1Bol
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm2.1Bol
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2.1, Alessandra Boletta
• MGI ID: MGI:4366012
• Synonyms: Pkd1^Flox, Pkd1^HA
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm2.1Bol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153606
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 45 and an HA tag, a loxP site, a myc tag, and an frt flanked neo cassette were inserted downstream of exon 46. Germ line, flp mediated recombination removed the neo cassette leaving exons 45 and 46 floxed. (J:153606)

Generation of the Pkd1^tm2.1Bol and Pkd1^tm2.2Bol alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:153606 Wodarczyk C, et al., A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One. 2009;4(9):e7137
• All: 8 reference(s)