Pkd1^tm3.1Bol
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm3.1Bol
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 3.1, Alessandra Boletta
• MGI ID: MGI:4366014
• Synonyms: Pkd1^Myc
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm3.1Bol page

Hydrocephalus in Pkd1^tm2.2Bol/Pkd1^tm3.1Bol Tg(Nes-cre)1Kln/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153606
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 45 and a myc tag, a loxP site, an HA tag, and an frt flanked neo cassette were inserted downstream of exon 46. Germ line, flp mediated recombination removed the neo cassette leaving exons 45 and 46 floxed. (J:153606)

Generation of the Pkd1^tm3.1Bol and Pkd1^tm3.2Bol alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:153606 Wodarczyk C, et al., A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One. 2009;4(9):e7137
• All: 2 reference(s)