Lrpap1^tm1Vln
Targeted Allele Detail

Summary

• Symbol: Lrpap1^tm1Vln
• Name: low density lipoprotein receptor-related protein associated protein 1; targeted mutation 1, Fred Van Leuven
• MGI ID: MGI:4366260
• Synonyms: RAP^-
• Gene: Lrpap1 Location: Chr5:35248834-35263043 bp, - strand Genetic Position: Chr5, 18.01 cM
• Alliance: Lrpap1^tm1Vln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107547
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last 68 bp of exon 6 and part of intron 6 was replaced with a PGK hygromycin B selection cassette. Northern blot analysis demonstrated only an abbreviated 1.6 kb mRNA. Western blot analysis failed to detect full lenght protein. A less than 30 kDa protein was found in kidneys but not elswhere. (J:107547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrpap1 Mutation: 24 strains or lines available

References

• Original: J:107547 Umans L, et al., Analysis of expression of genes involved in apolipoprotein E-based lipoprotein metabolism in pregnant mice deficient in the receptor-associated protein, the low density lipoprotein receptor, or apolipoprotein E. Biol Reprod. 1999 Nov;61(5):1216-25
• All: 1 reference(s)