Sox2^tm1.1Lan
Targeted Allele Detail

Summary

• Symbol: Sox2^tm1.1Lan
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Richard A Lang
• MGI ID: MGI:4366453
• Synonyms: Sox2^loxP, Sox2^tm1.1Apdn
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm1.1Lan page

Sox2^tm1.1Lan/Sox2^tm1.1Lan Tg(Scgb1a1-cre)1Kkw/0 mice show cuboidal-to-squamous epithelium lacking goblet, Clara and ciliated cells in the conducting airway epithelium

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152850
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted usptream of the coding exon and an frt flanked neo cassette with a 3' loxP site was inserted downstream of the exon. The frt flanked neo cassette used for selection was removed by germ line, flp mediated recombination. (J:152850)

Expression

In Mice Carrying this Mutation:	416158 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:152850 Shaham O, et al., Pax6 is essential for lens fiber cell differentiation. Development. 2009 Aug;136(15):2567-78
• All: 53 reference(s)