Hmgn3^tm1.2Mbus
Targeted Allele Detail

Summary

• Symbol: Hmgn3^tm1.2Mbus
• Name: high mobility group nucleosomal binding domain 3; targeted mutation 1.2, Michael Bustin
• MGI ID: MGI:4366465
• Synonyms: Hmgn3^tm1
• Gene: Hmgn3 Location: Chr9:82992001-83028738 bp, - strand Genetic Position: Chr9, 45.29 cM, cytoband E3.1
• Alliance: Hmgn3^tm1.2Mbus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153774
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombination removed exons 3 and 4. The absence of protein expression was confirmed by western blot analysis on brain, medulla oblongata, liver, and testis extracts. (J:153774)

Generation of the Hmgn3^tm1.2Mbus allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgn3 Mutation: 15 strains or lines available

References

• Original: J:153774 Ueda T, et al., The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion. Mol Cell Biol. 2009 Oct;29(19):5264-76
• All: 4 reference(s)