Dnm1l^tm1.1Hise
Targeted Allele Detail

Summary

• Symbol: Dnm1l^tm1.1Hise
• Name: dynamin 1-like; targeted mutation 1.1, Hiromi Sesaki
• MGI ID: MGI:4366510
• Synonyms: Drp1^fl, Drp1^loxP
• Gene: Dnm1l Location: Chr16:16130094-16176823 bp, - strand Genetic Position: Chr16, 10.12 cM
• Alliance: Dnm1l^tm1.1Hise page

Defects in cerebellar development in Dnm1l^tm1.1Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺ and Dnm1l^tm1.2Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153835
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed, frt flanked neo cassette was inserted downstream of exon 5. Germ line, flp mediated recombination removed the neo cassette leaving exons 3 through 5 floxed. (J:153835)

Expression

In Mice Carrying this Mutation:	94 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm1l Mutation: 44 strains or lines available

References

• Original: J:153835 Wakabayashi J, et al., The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol. 2009 Sep 21;186(6):805-16
• All: 32 reference(s)