Tg(Camk2a-App*,-Apbb1)25Spim
Transgene Detail

Summary

• Symbol: Tg(Camk2a-App*,-Apbb1)25Spim
• Name: transgene insertion 25, Sanjay W Pimplikar
• MGI ID: MGI:4366527
• Synonyms: FeCgamma.25
• Transgene: Tg(Camk2a-App*,-Apbb1)25Spim Location: unknown
• Alliance: Tg(Camk2a-App*,-Apbb1)25Spim page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-App*,-Apbb1)25Spim expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Apbb1 (29722)

  Apbb1

  (MGI:107765)

  mouse

  App (MGI:88059)

  The gene encodes a 59 residue long COOH-terminal fragment.

• Mutation details: This bigenic transgene line contains the intracellular domain of App and rat Apbb1 both driven by the mouse Camk2a promoter to achieve forebrain and hippocampal expression. Four lines were created (only lines 12 and 25 were named) that express both cDNAs. Line 25 was selected as the representative line. (J:102815)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:102815 Ryan KA, et al., Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol. 2005 Oct 24;171(2):327-35
• All: 6 reference(s)