Trpm6^tm1.1Rws
Targeted Allele Detail

Summary

• Symbol: Trpm6^tm1.1Rws
• Name: transient receptor potential cation channel, subfamily M, member 6; targeted mutation 1.1, Richard W Stokes
• MGI ID: MGI:4366769
• Gene: Trpm6 Location: Chr19:18727347-18869875 bp, + strand Genetic Position: Chr19, 13.21 cM
• Alliance: Trpm6^tm1.1Rws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153718
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning part of exon 5 through exon 7 was replaced with a floxed neo cassette. Germ line, cre mediated recombination removes the neo cassette. (J:153718)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm6 Mutation: 111 strains or lines available

References

• Original: J:153718 Walder RY, et al., Mice defective in Trpm6 show embryonic mortality and neural tube defects. Hum Mol Genet. 2009 Nov 15;18(22):4367-75
• All: 3 reference(s)