Cebpb^tm3Nerl
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm3Nerl
• Name: CCAAT/enhancer binding protein beta; targeted mutation 3, Claus Nerlov
• MGI ID: MGI:4366861
• Synonyms: betadeltacre
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm3Nerl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153686
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The cAMP response elements in the promoter region were replaced with 5 binding sites for the artificial ZFHD transcription factor. (J:153686)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 26 strains or lines available

References

• Original: J:153686 Ruffell D, et al., A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17475-80
• All: 1 reference(s)