Pole^tm1.1Bdp
Targeted Allele Detail

Summary

• Symbol: Pole^tm1.1Bdp
• Name: polymerase (DNA directed), epsilon; targeted mutation 1.1, Bradley Preston
• MGI ID: MGI:4366913
• Synonyms: Pole^e
• Gene: Pole Location: Chr5:110434185-110485319 bp, + strand Genetic Position: Chr5, 53.45 cM, cytoband E3-E5
• Alliance: Pole^tm1.1Bdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153684
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution converted the aspartic acid at position 272 and glutamic acid at position 274 to alalnenes. These changes modify the exonuclease active site. The floxed neo cassette used for selection was removed by germ line, cre mediated recombination. (J:153684)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pole^tm1.1Bdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pole Mutation: 99 strains or lines available

References

• Original: J:153684 Albertson TM, et al., DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17101-4
• All: 1 reference(s)