Dse^tm1Mmac
Targeted Allele Detail

Summary

• Symbol: Dse^tm1Mmac
• Name: dermatan sulfate epimerase; targeted mutation 1, Marco Maccarana
• MGI ID: MGI:4366965
• Gene: Dse Location: Chr10:34027389-34083711 bp, - strand Genetic Position: Chr10, 18.85 cM
• Alliance: Dse^tm1Mmac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153897
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 downstream of the translation initiation codon was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on spleen extracts. (J:153897)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dse Mutation: 105 strains or lines available

References

• Original: J:153897 Maccarana M, et al., Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin. Mol Cell Biol. 2009 Oct;29(20):5517-28
• All: 5 reference(s)