Sh3tc2^tm1.1Rchr
Targeted Allele Detail

Summary

• Symbol: Sh3tc2^tm1.1Rchr
• Name: SH3 domain and tetratricopeptide repeats 2; targeted mutation 1.1, Roman Chrast
• MGI ID: MGI:4367025
• Synonyms: Sh3tc2^deltaEx1
• Gene: Sh3tc2 Location: Chr18:62086002-62148790 bp, + strand Genetic Position: Chr18, 34.78 cM
• Alliance: Sh3tc2^tm1.1Rchr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153705
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with EGFP and a floxed neo cassette. Germ line, cre mediated recombination removes the neo cassette. (J:153705)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sh3tc2 Mutation: 61 strains or lines available

References

• Original: J:153705 Arnaud E, et al., SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17528-33
• All: 3 reference(s)