Myd88^tm1Jcbr
Targeted Allele Detail

Summary

• Symbol: Myd88^tm1Jcbr
• Name: myeloid differentiation primary response gene 88; targeted mutation 1, Jens C Bruning
• MGI ID: MGI:4367063
• Synonyms: Myd88^lox
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^tm1Jcbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153664
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 5. (J:153664)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 52 strains or lines available

References

• Original: J:153664 Kleinridders A, et al., MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009 Oct;10(4):249-59
• All: 7 reference(s)