Tg(tetO-HTR4*D100A)2Niss
Transgene Detail

Summary

• Symbol: Tg(tetO-HTR4*D100A)2Niss
• Name: transgene insertion 2, Robert A Nissenson
• MGI ID: MGI:4367596
• Synonyms: TetO-Rs1
• Transgene: Tg(tetO-HTR4*D100A)2Niss Location: unknown
• Alliance: Tg(tetO-HTR4*D100A)2Niss page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The transgene vector was constructed to contain an aspartic acid to alanine amino acid residue change at position 100 making the gene product insensitive to serotonin. It is under the control of a TetO promoter. Three lines were established and designated as B (or 2), C, and G (or 7). This transgene was originally designated as line B (or 2). This line shows slightly less expression than line G. (J:131617)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131617 Hsiao EC, et al., Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1209-14
• All: 3 reference(s)