Pde2a^tm1Dtst
Targeted Allele Detail

Summary

• Symbol: Pde2a^tm1Dtst
• Name: phosphodiesterase 2A, cGMP-stimulated; targeted mutation 1, Diane T Stephenson
• MGI ID: MGI:4367746
• Gene: Pde2a Location: Chr7:101070905-101162026 bp, + strand Genetic Position: Chr7, 54.57 cM
• Alliance: Pde2a^tm1Dtst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154140
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 28 bp sequence in exon 24 was replaced with a lacZ-neo cassette. This insertion disrupts the early portion of the catalytic domain. The absence of protein expression was confirmed by western blot analysis on neuroepithelium extracts. (J:154140)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde2a Mutation: 59 strains or lines available

References

• Original: J:154140 Stephenson DT, et al., Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species. J Histochem Cytochem. 2009 Oct;57(10):933-49
• All: 1 reference(s)