Foxo1^tm1.1Stlp
Targeted Allele Detail

Summary

• Symbol: Foxo1^tm1.1Stlp
• Name: forkhead box O1; targeted mutation 1.1, Stanford L Peng
• MGI ID: MGI:4367752
• Synonyms: Foxo1^flox
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^tm1.1Stlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Germ line, flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:154205)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 32 strains or lines available

References

• Original: J:154205 Gubbels Bupp MR, et al., T cells require Foxo1 to populate the peripheral lymphoid organs. Eur J Immunol. 2009 Aug 5;39(11):2991-2999
• All: 4 reference(s)