Kdr^tm1.1Jamb
Targeted Allele Detail

Summary

• Symbol: Kdr^tm1.1Jamb
• Name: kinase insert domain protein receptor; targeted mutation 1.1, Jayakrishna Ambati
• MGI ID: MGI:4367756
• Synonyms: Vegfr2^flox
• Gene: Kdr Location: Chr5:76093487-76139118 bp, - strand Genetic Position: Chr5, 40.23 cM
• Alliance: Kdr^tm1.1Jamb page

Suppression of of extraretinal vascular outgrowth in ischemic Kdr^tm1.1Jamb/Kdr^tm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154336
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Germ line, flp mediated recombination removes the neo cassette leaving exon 1 floxed. (J:154336)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdr Mutation: 74 strains or lines available

References

• Original: J:154336 Albuquerque RJ, et al., Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med. 2009 Sep;15(9):1023-30
• All: 9 reference(s)