Ahi1^tm1Jgg
Targeted Allele Detail

Summary

• Symbol: Ahi1^tm1Jgg
• Name: Abelson helper integration site 1; targeted mutation 1, Joseph G Gleeson
• MGI ID: MGI:4367773
• Gene: Ahi1 Location: Chr10:20828446-20956328 bp, + strand Genetic Position: Chr10, 9.75 cM, cytoband A3
• Alliance: Ahi1^tm1Jgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154321
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6 and a floxed neo cassette was inserted downstream of exon 7. Cre-mediated recombination removed exon 6 and 7 and the neo cassette. The lack of protein expression was confirmed by western blot analysis on brain extracts. (J:158019)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahi1 Mutation: 80 strains or lines available

References

• Original: J:154321 Lancaster MA, et al., Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med. 2009 Sep;15(9):1046-54
• All: 4 reference(s)