Tg(Gfap-cre/PGR*)473Gkl
Transgene Detail

Summary

• Symbol: Tg(Gfap-cre/PGR*)473Gkl
• Name: transgene insertion 473, George Kollias
• MGI ID: MGI:4367775
• Synonyms: GFAP-CrePR, Tg(Gfap-cre/PGR)473Gkl, Tg(GFAP-cre,PGR)473Gkl
• Transgene: Tg(Gfap-cre/PGR*)473Gkl Location: unknown
• Alliance: Tg(Gfap-cre/PGR*)473Gkl page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Tg(Gfap-cre/PGR*)473Gkl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gfap (MGI:95697)

• Mutation details: This transgene contains the mouse glial fibrillary acidic protein promoter driving the expression of an RU486-inducible Cre recombinase. The encoded protein is a fusion of Cre recombinase with a mutant human progesterone receptor that fails to bind to its natural ligand at physiologic concentrations but does bind to the synthetic progesterone analog RU486. The unbound fusion protein is restricted to the cytoplasm; it can enter the nucleus only when bound to RU486. (J:115216)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gfap (mouse) Summary of all recombinase alleles driven by Gfap. Alliance mouse Gfap gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:115216 MUGEN, Information obtained from the Network of Excellence in Integrated Functional Genomics in Mutant Mouse Models as tools to investigate the complexity of Human Immunological Disease (MUGEN). Unpublished. 2006-2015
• All: 1 reference(s)