Tg(Pomc-cre)5Brn
Transgene Detail

Summary

• Symbol: Tg(Pomc-cre)5Brn
• Name: transgene insertion 5, Anton Berns
• MGI ID: MGI:4367779
• Synonyms: Tg(Pomc1-cre)1Brn, Tg(Pomc-cre)1Brn, Tg(PomcCre)5Brn
• Transgene: Tg(Pomc-cre)5Brn Location: unknown
• Alliance: Tg(Pomc-cre)5Brn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pomc-cre)5Brn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pomc

• Mutation details: This transgene contains 706 base pairs of 5' flanking sequence containing the promoter of the rat pro-opiomelanocortin gene followed by the coding sequence for Cre recombinase with an amino-terminal nuclear localization signal (nlsCre), a synthetic intron, and SV40 splice and polyadenylation signals. Progeny of mice bearing this transgene crossed to lacZ Cre reporter mice exhibited large numbers of X-gal staining cells in the intermediate lobe and lesser staining in the anterior lobe of the pituitary gland. (J:80158)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pomc (species not specified) Summary of all recombinase alleles driven by Pomc. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This is one of six transgenic lines generated.

References

• Original: J:80158 Akagi K, et al., Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res. 1997 May 1;25(9):1766-73
• All: 4 reference(s)