Aplnr^tm1.1Tq
Targeted Allele Detail

Summary

• Symbol: Aplnr^tm1.1Tq
• Name: apelin receptor; targeted mutation 1.1, Thomas Quertermous
• MGI ID: MGI:4367882
• Synonyms: APJ^-
• Gene: Aplnr Location: Chr2:84966704-84970267 bp, + strand Genetic Position: Chr2, 49.45 cM, cytoband E1
• Alliance: Aplnr^tm1.1Tq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154303
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A coding exon was flanked with a lox P site and a loxP-flanked neomycin selection cassette. Transient cre expression in ES cells removed the neomycin selection cassette and coding exon. (J:154303)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplnr Mutation: 30 strains or lines available

References

• Original: J:154303 Charo DN, et al., Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1904-13
• All: 7 reference(s)