Dp(17Abcg1-Cbs)1Yah
Targeted Allele Detail

Summary

• Symbol: Dp(17Abcg1-Cbs)1Yah
• Name: duplication, Chr 17, Yann Herault 1
• MGI ID: MGI:4367905
• Synonyms: Dp(17)1Yah, Dp(17Abcg1-U2af1)1Yah, Dup(17Abcg1-U2af1), Ts1Yah
• Gene: Dp(17Abcg1-Cbs)1Yah Location: Chr17:31276672-31856173 bp Genetic Position: Chr17, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154298
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutations: Duplication, Insertion
• Dp(17Abcg1-Cbs)1Yah involves 19 genes/genome features (Gm25447, Gm24970, Abcg1 ...) View all
• Mutation details: This duplication was created by cre mediated recombination in ES cells of loxP sites within targeted knock-ins at Abcg1 (containing a duplicated exons 14 and 15, neo cassette, loxP site, and 5' Hprt minigene; Abcg1tm1Yah) and between Cba and U2af1 (containing a 3' Hprt mini gene, loxP, and puro cassette; Is(17B1)1Yah). The duplication spans a 0.59 Mb interval between Abcg1 and U2af1 that contains part of Abcg1, all of Tff3, Tff2, Tff1, Tmprss3, Ubash3a, Rsph1, Slc37a1, Pde9a, Wdr4, 1500032D16RIK (Ndufv3), Pknox1, and Cbs but does not include U2af1. (J:154298)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(17Abcg1-Cbs)1Yah Mutation: 1 strain or line available

References

• Original: J:154298 Pereira PL, et al., A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet. 2009 Dec 15;18(24):4756-4769
• All: 4 reference(s)