Cngb3^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Cngb3^tm1Dgen
• Name: cyclic nucleotide gated channel beta 3; targeted mutation 1, Deltagen
• MGI ID: MGI:4367989
• Gene: Cngb3 Location: Chr4:19280850-19510623 bp, + strand Genetic Position: Chr4, 7.42 cM, cytoband A3
• Alliance: Cngb3^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The sequence from bases 733 to 749 of the transcript (GenBank accession number AJ243572) were removed by targeted deletion. The absence of protein expression was confirmed by immunofluorescence labeling of retinal sections. (J:154304)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cngb3 Mutation: 41 strains or lines available

References

• Original: J:154304 Ding XQ, et al., Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism. Hum Mol Genet. 2009 Dec 15;18(24):4770-4780
• All: 11 reference(s)