Tbx21^duane
Chemically induced Allele Detail

Summary

• Symbol: Tbx21^duane
• Name: T-box 21; Duane
• MGI ID: MGI:4367995
• Synonyms: Tbx21^du
• Gene: Tbx21 Location: Chr11:96988897-97006157 bp, - strand Genetic Position: Chr11, 60.95 cM, cytoband D
• Alliance: Tbx21^duane page

Mutation origin

• Strain of Origin: C57BL/6
• Project Collection: APF ENU Mutagenesis

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU mutagenesis induced a point mutation (T to A chr 11: 96973058) in the second intron altering the splice acceptor site and thereby preventing normal splicing. This mutation deletes 8 amino acids from the final peptide. Activated splenocytes exhibit a 3- to 4-fold decrease in protein expression compared with similarly treated wild-type cells. (J:154069) Inheritance: Recessive

Location of the Tbx21^duane mutation

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tbx21 Mutation: 39 strains or lines available

References

• Original: J:154069 Jenne CN, et al., T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 2009 Oct 26;206(11):2469-81
• All: 3 reference(s)