Gldc^{Gt(EUCG0001d02)Hmgu}
Gene trapped Allele Detail

Summary

• Symbol: Gldc^{Gt(EUCG0001d02)Hmgu}
• Name: glycine decarboxylase; gene trap EUCG0001d02, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:4380899
• Synonyms: Gldc^GT1
• Gene: Gldc Location: Chr19:30075847-30152829 bp, - strand Genetic Position: Chr19, 24.87 cM, cytoband C
• Alliance: Gldc^{Gt(EUCG0001d02)Hmgu} page

Mutation origin

• Mutant Cell Line: EUCG0001d02
• Germline Transmission: Earliest citation of germline transmission: J:221782
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: rsFlipROSAbgeo*
• Mutation details: A gene trap vector consisting of long terminal repeats flanking a construct with pairs of FRT, F3, loxP and lox5171 sites surrounding a splice acceptor-neo-polyA cassette was inserted in intron 2. qRT-PCR analysis indicates that mRNA is diminished by 80-90% in homozygotes, indicating this is a strong hypomorphic allele. (J:221782)
• Sequence Tags: Sequence tag details (2 tags)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  EUCG0001d02.q1k5SPK	FI545224 ; (MGI Seq Detail)	5'Splinkerette PCR	Chr19:30148972-30149282 bp (-)
  EUCG0001d02.p1k3SPK	FI538173 ; (MGI Seq Detail)	3'Splinkerette PCR	unknown
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gldc Mutation: 70 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 7 reference(s)