Lnpep^tm1.1Sych
Targeted Allele Detail

Summary

• Symbol: Lnpep^tm1.1Sych
• Name: leucyl/cystinyl aminopeptidase; targeted mutation 1.1, Siew Yeen Chai
• MGI ID: MGI:4397580
• Synonyms: IRAP^-
• Gene: Lnpep Location: Chr17:17747985-17846303 bp, - strand Genetic Position: Chr17, 9.77 cM
• Alliance: Lnpep^tm1.1Sych page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154386
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removes exon 2 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, muscle, and fat extracts. (J:154386)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lnpep Mutation: 100 strains or lines available

References

• Original: J:154386 Albiston AL, et al., Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory. Neurobiol Learn Mem. 2010 Jan;93(1):19-30
• All: 3 reference(s)