Sort1^tm1Camo
Targeted Allele Detail

Summary

• Symbol: Sort1^tm1Camo
• Name: sortilin 1; targeted mutation 1, Carlos R Morales
• MGI ID: MGI:4397584
• Synonyms: sortilin^-
• Gene: Sort1 Location: Chr3:108191398-108268827 bp, + strand Genetic Position: Chr3, 46.9 cM, cytoband F3
• Alliance: Sort1^tm1Camo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154468
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The segement between exon 2 and intron 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, lung, and testis extracts. (J:154468)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sort1 Mutation: 49 strains or lines available

References

• Original: J:154468 Zeng J, et al., The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes. Exp Cell Res. 2009 Nov 1;315(18):3112-24
• All: 9 reference(s)