Prss21^tm1Anta
Targeted Allele Detail

Summary

• Symbol: Prss21^tm1Anta
• Name: serine protease 21; targeted mutation 1, Toni M Antalis
• MGI ID: MGI:4397679
• Gene: Prss21 Location: Chr17:24087046-24092087 bp, + strand Genetic Position: Chr17, 12.11 cM, cytoband A3.3-B
• Alliance: Prss21^tm1Anta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154521
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning exon 4, 5, and the coding region of exon 6 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on testis extract. (J:154521)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Prss21^tm1Anta/Prss21^tm1Anta	involves: NIH Black Swiss

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
cellular		√
oligozoospermia		√
teratozoospermia		√
abnormal sperm flagellum morphology		√
coiled sperm flagellum		√
detached sperm flagellum		√
hairpin sperm flagellum		√
abnormal sperm head morphology		√
decreased sperm progressive motility		√
reproductive system	√	√
abnormal spermatogenesis		√
oligozoospermia		√
teratozoospermia		√
abnormal sperm flagellum morphology		√
coiled sperm flagellum		√
detached sperm flagellum		√
hairpin sperm flagellum		√
abnormal sperm head morphology		√
impaired fertilization	√	√
decreased fertilization frequency	√	√
abnormal sperm physiology		√
decreased sperm progressive motility		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss21 Mutation: 14 strains or lines available

References

• Original: J:154521 Netzel-Arnett S, et al., The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. Biol Reprod. 2009 Nov;81(5):921-32
• All: 1 reference(s)