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Prss21tm1Anta
Targeted Allele Detail
Summary
Symbol: Prss21tm1Anta
Name: serine protease 21; targeted mutation 1, Toni M Antalis
MGI ID: MGI:4397679
Gene: Prss21  Location: Chr17:24087046-24092087 bp, + strand  Genetic Position: Chr17, 12.11 cM, cytoband A3.3-B
Alliance: Prss21tm1Anta page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154521
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe genomic sequence spanning exon 4, 5, and the coding region of exon 6 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on testis extract. (J:154521)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: NIH Black Swiss
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
cellular
oligozoospermia
teratozoospermia
abnormal sperm flagellum morphology
coiled sperm flagellum
detached sperm flagellum
hairpin sperm flagellum
abnormal sperm head morphology
decreased sperm progressive motility
reproductive system
abnormal spermatogenesis
oligozoospermia
teratozoospermia
abnormal sperm flagellum morphology
coiled sperm flagellum
detached sperm flagellum
hairpin sperm flagellum
abnormal sperm head morphology
impaired fertilization
decreased fertilization frequency
abnormal sperm physiology
decreased sperm progressive motility
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prss21 Mutation:  14 strains or lines available
References
Original:  J:154521 Netzel-Arnett S, et al., The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. Biol Reprod. 2009 Nov;81(5):921-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory