Pdcd1^tm1.1Shr
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm1.1Shr
• Name: programmed cell death 1; targeted mutation 1.1, Arlene H Sharpe
• MGI ID: MGI:4397682
• Synonyms: PD-1^-
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm1.1Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153040
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. Transient cre expression in ES cells removed exons 2 and 3 along with the neo cassette. (J:153040)

Expression

In Mice Carrying this Mutation:

5 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 97 strains or lines available

References

• Original: J:153040 Keir ME, et al., PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol. 2007 Oct 15;179(8):5064-70
• All: 69 reference(s)