Sox2^tm4.1Skn
Targeted Allele Detail

Summary

• Symbol: Sox2^tm4.1Skn
• Name: SRY (sex determining region Y)-box 2; targeted mutation 4.1, Silvia K Nicolis
• MGI ID: MGI:4397705
• Synonyms: Sox2^fl, Sox2^loxPdeltaneo
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm4.1Skn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154650
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the coding region and an frt flanked neo cassette with a 5' loxP site was inserted downstream of the coding regon. Germ line, flp mediated recombination removed the neo cassette leaving the coding region floxed. (J:154650)

Expression

In Mice Carrying this Mutation:	136 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:154650 Favaro R, et al., Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci. 2009 Oct;12(10):1248-56
• All: 26 reference(s)