Tg(Sox2-cre/ERT2)1Skn
Transgene Detail

Summary

• Symbol: Tg(Sox2-cre/ERT2)1Skn
• Name: transgene insertion 1, Silvia K Nicolis
• MGI ID: MGI:4397776
• Synonyms: Sox2-creERT2
• Transgene: Tg(Sox2-cre/ERT2)1Skn Location: unknown
• Alliance: Tg(Sox2-cre/ERT2)1Skn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Sox2-cre/ERT2)1Skn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Sox2

• Mutation details: 5.7 kb of the 5' telencephalic enhancer/promoter was used to drive inducible, telencephalic-specific expression of a cre/estrogen receptor (ERT2) fusion. Six lines were created and the one with the most efficient activity was used in subsequent experiments. (J:154650)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (species not specified) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:154650 Favaro R, et al., Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci. 2009 Oct;12(10):1248-56
• All: 3 reference(s)