Grik4^{tm1.1(cre)Slab}
Targeted Allele Detail

Summary

• Symbol: Grik4^{tm1.1(cre)Slab}
• Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1.1, Ralf Schoepfer
• MGI ID: MGI:4398684
• Synonyms: CA3-cre
• Gene: Grik4 Location: Chr9:42431708-42856296 bp, - strand Genetic Position: Chr9, 23.8 cM
• Alliance: Grik4^{tm1.1(cre)Slab} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154648
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Grik4^{tm1.1(cre)Slab} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grik4 (MGI:95817)

• Mutation details: A cassette containing an IRES sequence, EGFP/cre fusion, and frt flanked neo and histidine markers was inserted into the 3' UTR. Germ line, flp mediated recombination removed the neo and histidine markers. Cre activity is detected in nearly all cells in the CA3 and a smaller fraction of dentate gyrus cells starting at postnatal week 1. (J:154648)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grik4 (mouse) Summary of all recombinase alleles driven by Grik4. Alliance mouse Grik4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Grik4 Mutation: 48 strains or lines available

References

• Original: J:154648 Filosa A, et al., Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci. 2009 Oct;12(10):1285-92
• All: 2 reference(s)