Hyal5^tm1Tba
Targeted Allele Detail

Summary

• Symbol: Hyal5^tm1Tba
• Name: hyaluronoglucosaminidase 5; targeted mutation 1, Tadashi Baba
• MGI ID: MGI:4398725
• Synonyms: Hyal5^-
• Gene: Hyal5 Location: Chr6:24857996-24891957 bp, + strand Genetic Position: Chr6, 11.28 cM, cytoband A3
• Alliance: Hyal5^tm1Tba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154516
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced 1756 nucleotides of the Hyal5 gene including the 1139 bp of exon 2. No mRNA or protein was detected by Northern or Western Blot in homozygous mice. (J:154516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hyal5 Mutation: 31 strains or lines available

References

• Original: J:154516 Kimura M, et al., Functional roles of mouse sperm hyaluronidases, HYAL5 and SPAM1, in fertilization. Biol Reprod. 2009 Nov;81(5):939-47
• All: 1 reference(s)