Hbegf^tm1Hhar
Targeted Allele Detail

Summary

• Symbol: Hbegf^tm1Hhar
• Name: heparin-binding EGF-like growth factor; targeted mutation 1, Hideaki Hara
• MGI ID: MGI:4398735
• Gene: Hbegf Location: Chr18:36637980-36648858 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Hbegf^tm1Hhar page

Morphological changes in the prefrontal cortex of Hbegf^tm1Hhar/Hbegf^tm1Hhar Tg(Six3-cre)69Frty/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154094
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutations: Insertion, Intragenic deletion Mutation details: The full length cDNA, including poly A site was flanked by lox P sites and followed by a LacZ reporter, and replaced exons 1-3. A neo cassette driven by phosphoglycerate kinase promoter and the diphtheria toxinA fragment (DT-A) was placed within intron 3. sequence. (J:154094)

Generation of the Hbegf^tm1Hhar allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hbegf Mutation: 26 strains or lines available

References

• Original: J:154094 Oyagi A, et al., Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice. PLoS One. 2009;4(10):e7461
• All: 3 reference(s)