Skil^tm1.1Kluo
Targeted Allele Detail

Summary

• Symbol: Skil^tm1.1Kluo
• Name: SKI-like; targeted mutation 1, Kunxin Luo
• MGI ID: MGI:4398740
• Synonyms: SnoN^m
• Gene: Skil Location: Chr3:31149259-31176741 bp, + strand Genetic Position: Chr3, 15.12 cM
• Alliance: Skil^tm1.1Kluo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154718
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with a modified exon 1 in which the codons corresponding to the residues 85 through 88 (the R-Smad binding site) and 266 through 267 (the Co-Smad binding site) were altered to code for alanines. A floxed neo cassette was inserted downsteam of the modified exon 1 and subsequently removed by germ line, cre mediated recombination. This allele is predicted to produce a protein product incapable of interacting with R-Smads and Smad4. (J:154718)

Expression

In Mice Carrying this Mutation:

25 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Skil Mutation: 39 strains or lines available

References

• Original: J:154718 Pan D, et al., SnoN functions as a tumour suppressor by inducing premature senescence. EMBO J. 2009 Nov 18;28(22):3500-13
• All: 5 reference(s)