Camk2g^tm1.1Irt
Targeted Allele Detail

Summary

• Symbol: Camk2g^tm1.1Irt
• Name: calcium/calmodulin-dependent protein kinase II gamma; targeted mutation 1.1, Ira Tabas
• MGI ID: MGI:4398829
• Gene: Camk2g Location: Chr14:20784943-20844156 bp, - strand Genetic Position: Chr14, 11.53 cM
• Alliance: Camk2g^tm1.1Irt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154647
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removes exon 1 and 2. Exon 2 encodes part of the catalytic domain including the ATP binding motif essential for kinase function. The absence of protein expression was confirmed by western blot analysis of macrophage extracts. (J:154647)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2g Mutation: 38 strains or lines available

References

• Original: J:154647 Timmins JM, et al., Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest. 2009 Oct;119(10):2925-41
• All: 14 reference(s)