Vps53^tm1Xtz
Targeted Allele Detail

Summary

• Symbol: Vps53^tm1Xtz
• Name: VPS53 GARP complex subunit; targeted mutation 1, XT Zhao
• MGI ID: MGI:4398894
• Synonyms: HCCS1^-
• Gene: Vps53 Location: Chr11:75937052-76070464 bp, - strand Genetic Position: Chr11, 45.92 cM, cytoband B4
• Alliance: Vps53^tm1Xtz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154272
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced with a neo cassette. (J:154272)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps53 Mutation: 40 strains or lines available

References

• Original: J:154272 Gan Y, et al., HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality. Cell Death Differ. 2008 Sep;15(9):1481-90
• All: 1 reference(s)