Acvrl1^tm2.1Spo
Targeted Allele Detail

Summary

• Symbol: Acvrl1^tm2.1Spo
• Name: activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
• MGI ID: MGI:4398901
• Synonyms: Alk1^1f/2f, Alk1^2loxP
• Gene: Acvrl1 Location: Chr15:101026403-101043217 bp, + strand Genetic Position: Chr15, 56.41 cM, cytoband F3
• Alliance: Acvrl1^tm2.1Spo page

Arteriovenous malformations in the brain, lung, and GI tract of Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice

Show the 10 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130020
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Germ line, cre mediated recombination removed the neo cassette leaving exons 4 through 6 floxed. (J:130020)

Disease models

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvrl1 Mutation: 27 strains or lines available

References

• Original: J:130020 Park SO, et al., ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood. 2008 Jan 15;111(2):633-42
• All: 29 reference(s)