Tg(Acvrl1-cre)L1Spo
Transgene Detail

Summary

• Symbol: Tg(Acvrl1-cre)L1Spo
• Name: transgene insertion L1, S Paul Oh
• MGI ID: MGI:4398903
• Synonyms: L1cre, Tg(Alk1-cre)-L1
• Transgene: Tg(Acvrl1-cre)L1Spo Location: unknown
• Alliance: Tg(Acvrl1-cre)L1Spo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Acvrl1-cre)L1Spo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Acvrl1

• Mutation details: The 9.2 Kb regulatory fragment 1 is followed by an SV40 splice donor and acceptor, an IRES sequence, and a cre recombinase gene. Several founders were generated and several lines were created (including lines B, D, and L1). Line L1 exhibits cre activity at E13.5 in lung endothelial cells and at E15.5 in the lung endothelial cells and extraembryonic vessels. (J:130020)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acvrl1 (species not specified) Summary of all recombinase alleles driven by Acvrl1. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130020 Park SO, et al., ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood. 2008 Jan 15;111(2):633-42
• All: 13 reference(s)