Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:4398910
• Synonyms: Bmi1^LSL, Bmi-CTS, Gt(ROSA)26Sor^{tm1(CMV-Bmi1,-EGFP)Nki}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki} page

Pituitary tumor in Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Tg(Gfap-cre)2Brn/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184533
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: The targeting construct contains a CAG promoter, a floxed transcriptional stop cassette [PGK promoter neo triple poly A] followed by a cDNA encoding mouse Bmi1 and a downstream ires-eGFP cassette. Conditional excision of the poly A signals results in expression of the two inserted constructs under the control of the CAG promoter. (J:184533)

Generation of the Gt(ROSA)26Sor^tm1(CAG-Bmi1,-EGFP)Nki allele

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:184533 Nacerddine K, et al., Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest. 2012 May 1;122(5):1920-32
• All: 3 reference(s)