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Steap3tm1.1Atel
Targeted Allele Detail
Summary
Symbol: Steap3tm1.1Atel
Name: STEAP family member 3; targeted mutation 1.1, Adam Telerman
MGI ID: MGI:4398911
Synonyms: TSAP6-, Tsap6del2-3, TSAP6 KO
Gene: Steap3  Location: Chr1:120154137-120198810 bp, - strand  Genetic Position: Chr1, 52.66 cM, cytoband E2
Alliance: Steap3tm1.1Atel page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154356
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 46 bp polynucleotide containing a LoxP site was added 404bp upstream exon 2, and a neomycin resistance gene floxed by two LoxP sites was added 533bp downstream exon 3. Cre-mediated excision of exons 2-3 was achieved upon electroporation of a Cre-recombinase expression vector in the correctly targeted ES clones. Protein was undetected in homozygous mutant mice by Western blot analysis and Immnunohistological staining. (J:154356)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Steap3 Mutation:  63 strains or lines available
References
Original:  J:154356 Lespagnol A, et al., Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 2008 Nov;15(11):1723-33
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory