Timp3^tm1Osya
Targeted Allele Detail

Summary

• Symbol: Timp3^tm1Osya
• Name: tissue inhibitor of metalloproteinase 3; targeted mutation 1, Osamu Yasuda
• MGI ID: MGI:4398972
• Gene: Timp3 Location: Chr10:86136276-86185369 bp, + strand Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
• Alliance: Timp3^tm1Osya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154849
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on kidney extracts. (J:154849)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Timp3 Mutation: 19 strains or lines available

References

• Original: J:154849 Kawamoto H, et al., Tissue inhibitor of metalloproteinase-3 plays important roles in the kidney following unilateral ureteral obstruction. Hypertens Res. 2006 Apr;29(4):285-94
• All: 13 reference(s)