Timp3^tm1Osya
Targeted Allele Detail

Summary

• Symbol: Timp3^tm1Osya
• Name: tissue inhibitor of metalloproteinase 3; targeted mutation 1, Osamu Yasuda
• MGI ID: MGI:4398972
• Gene: Timp3 Location: Chr10:86136276-86185369 bp, + strand Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
• Alliance: Timp3^tm1Osya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154849
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on kidney extracts. (J:154849)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Timp3^tm1Osya/Timp3^tm1Osya	B6.129P2-Timp3^tm1Osya
hm2	Timp3^tm1Osya/Timp3^tm1Osya	involves: 129P2/OlaHsd * C57BL/6
hm3	Timp3^tm1Osya/Timp3^tm1Osya	involves: 129P2/OlaHsd * C57BL/6J
cx4	Mmp2^tm1Ito/Mmp2^tm1Ito Timp3^tm1Osya/Timp3^tm1Osya	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1		hm2	hm3	cx4
show or hide all annotated terms Sex:
behavior/neurological			√
behavior/neurological phenotype			N
abnormal learning/memory/conditioning			√
abnormal spatial learning			√
cardiovascular system	N	√	√		√
cardiovascular system phenotype	N	N	N
abnormal artery morphology			√
abnormal aorta morphology		√
abnormal aorta wall morphology		√			√
abnormal abdominal aorta morphology		√			√
abdominal aorta aneurysm		√
abnormal blood vessel elastic tissue morphology			√
increased susceptibility to induced aneurysm formation					√
abnormal systemic arterial blood pressure			√
decreased systemic arterial blood pressure			√
abnormal blood vessel physiology		√	√
decreased vasodilation			√
aortitis		√			√
growth/size/body	√	√
enlarged kidney	√	√
homeostasis/metabolism	√	√		√
decreased susceptibility to induced hypothermia				√
increased body temperature				√
increased carbon dioxide production				√
increased oxygen consumption				√
increased susceptibility to injury	√	√
immune system		√			√
aortitis		√			√
mortality/aging		√			√
increased susceptibility to induced morbidity/mortality					√
premature death		√
muscle			√
decreased vasodilation			√
renal/urinary system	√	√
abnormal kidney morphology	√	√
enlarged kidney	√	√
hydronephrosis	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Timp3 Mutation: 19 strains or lines available

References

• Original: J:154849 Kawamoto H, et al., Tissue inhibitor of metalloproteinase-3 plays important roles in the kidney following unilateral ureteral obstruction. Hypertens Res. 2006 Apr;29(4):285-94
• All: 13 reference(s)