Tg(Myh6-Camk2d)1Jhb
Transgene Detail

Summary

• Symbol: Tg(Myh6-Camk2d)1Jhb
• Name: transgene insertion 1, Joan Heller Brown
• MGI ID: MGI:4399096
• Synonyms: Tg(Myh6-Camk2d_ib)1Jhb
• Transgene: Tg(Myh6-Camk2d)1Jhb Location: unknown
• Alliance: Tg(Myh6-Camk2d)1Jhb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Camk2d)1Jhb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Camk2d (24246)

  Camk2d

  (MGI:1341265)

• Mutation details: A hemagglutinin tagged rat cDNA for the B splice variant of Camk2d was placed under the control of the murine heart alpha myosin promoter. The gene is overexpressed 10 fold in the heart by Western blot and enzyme activity is elevated 4 fold. (J:73694)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73694 Zhang T, et al., The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem. 2002 Jan 11;277(2):1261-7
• All: 4 reference(s)