Wnt4^tm1.1Svo
Targeted Allele Detail

Summary

• Symbol: Wnt4^tm1.1Svo
• Name: wingless-type MMTV integration site family, member 4; targeted mutation 1.1, Seppo Vainio
• MGI ID: MGI:4399114
• Synonyms: Wnt4^c
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^tm1.1Svo page

Impaired kidney development in Wnt4^tm1.1Svo/Wnt4^tm1.1Svo Tg(CAG-cre)13Miya/0 fetuses

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154784
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo cassette was inserted downstream of exon 5. Germ line, cre mediated recombination removed the neo cassette leaving exons 3 through 5 floxed. (J:154784)

Generation of the Wnt4^tm1Svo and Wnt4^tm1.1Svo alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 21 strains or lines available

References

• Original: J:154784 Shan J, et al., Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse. Genesis. 2009 Nov;47(11):782-8
• All: 10 reference(s)