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Tcf3tm6(Esr1*)Zhu
Targeted Allele Detail
Summary
Symbol: Tcf3tm6(Esr1*)Zhu
Name: transcription factor 3; targeted mutation 6, Yuan Zhuang
MGI ID: MGI:4399144
Synonyms: E2AER, Tcf3tm6Zhu
Gene: Tcf3  Location: Chr10:80245348-80269481 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance: Tcf3tm6(Esr1*)Zhu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154788
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Inducible)
Inducer:    tamoxifen
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThe tamoxifen-responsive region from the mouse Esr1 gene with the G525R mutation was inserted at a modified STOP codon in Tcf3tm5Zhu replacing the GFP coding region. A neo cassette was also inserted for selection purposes. Both the E12 and E47 forms contain the modification resulting in tamoxifen-inducible function. (J:154788)
Generation of the Tcf3tm6(Esr1*)Zhu allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf3 Mutation:  43 strains or lines available
References
Original:  J:154788 Jones ME, et al., A tamoxifen inducible knock-in allele for investigation of E2A function. BMC Dev Biol. 2009;9:51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory