Prr7^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Prr7^{tm1(KOMP)Vlcg}
• Name: proline rich 7 (synaptic); targeted mutation 1, Velocigene
• MGI ID: MGI:4399196
• Synonyms: Prr7^-
• Gene: Prr7 Location: Chr13:55612080-55620967 bp, + strand Genetic Position: Chr13, 30.06 cM
• Alliance: Prr7^{tm1(KOMP)Vlcg} page
• IMPC: Prr7 gene page

Mutation origin

• Mutant Cell Lines: 10972A-A2, 10972A-A6, 10972A-A8, 10972A-D4, 10972A-E12, 10972A-F9
• Germline Transmission: Earliest citation of germline transmission: J:237776
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1 Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1011bp between positions 55619824-55620834 of Chromosome 13 (Build GRCm39). The entire coding region was replaced by a cassette containing the lacZ gene expressed under control of the endogenous promoter and an independently expressed neomycin resistance gene. Immunoblotting of brain lysates confirmed the absence of protein expression in homozygous mutant mice. (J:136110, J:237776)

Generation of the Prr7^tm1(KOMP)Vlcg allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Prr7 Mutation: 11 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)