B4gat1^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: B4gat1^{tm1(KOMP)Vlcg}
• Name: beta-1,4-glucuronyltransferase 1; targeted mutation 1, Velocigene
• MGI ID: MGI:4399423
• Gene: B4gat1 Location: Chr19:5088854-5091159 bp, + strand Genetic Position: Chr19, 4.23 cM
• Alliance: B4gat1^{tm1(KOMP)Vlcg} page
• IMPC: B4gat1 gene page

Mutation origin

• Mutant Cell Lines: 12887A-D1, 12887A-D3, 12887A-G1, 12887A-G3
• Germline Transmission: Earliest citation of germline transmission: J:194150
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1573bp between positions 5089008-5090580 of Chromosome 19 (Build GRCm39). The coding sequence was replaced with lacZ. (J:136110, J:194150)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any B4gat1 Mutation: 18 strains or lines available

Notes

Cell line 12887A-D3 and 12887A-G3 were successfully used to make chimeric mice. Germline transmission was accomplished for both lines. 12887A-G3 strain as the founder for the B3gnt1-LacZ mouse line in J:194150.

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 2 reference(s)