Lypd3^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Lypd3^{tm1(KOMP)Vlcg}
• Name: Ly6/Plaur domain containing 3; targeted mutation 1, Velocigene
• MGI ID: MGI:4399526
• Synonyms: C4.4A^-
• Gene: Lypd3 Location: Chr7:24335995-24340543 bp, + strand Genetic Position: Chr7, 11.95 cM, cytoband A3
• Alliance: Lypd3^{tm1(KOMP)Vlcg} page
• IMPC: Lypd3 gene page

Mutation origin

• Mutant Cell Lines: 13176A-B8, 13176A-C11, 13176A-E7, 13176A-E10, 13176A-F5
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 4068bp between positions 24336018-24340085 of Chromosome 7 (Build GRCm39). Exons 1-5 were replaced by a beta-galactosidase reporter gene and a neomycin resistance cassette. Immunohistochemical staining of the esophagus confirmed the absence of protein expression in homozygous mutant mice. (J:136110, J:235771)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Lypd3 Mutation: 22 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)