Gt(ROSA)26Sor^{tm4(CAG-hsb5)Nki}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm4(CAG-hsb5)Nki}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, The Netherlands Cancer Institute
• MGI ID: MGI:4410291
• Synonyms: Rosa26^flox-SB, Rosa26^Lox66SBLox71
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm4(CAG-hsb5)Nki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172071
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Transposase)
• Mutation: Insertion
• Mutation details: An inverted cassette containing a hyperactive sleeping beauty transposase variant hsb5 under the control of the CAG promoter flanked lox66 and lox71 sites was cloned into the Gt(Rosa)26Sor locus. (J:172071, J:178629)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm4(CAG-hsb5)Nki}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:172071 Vassiliou GS, et al., Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet. 2011 May;43(5):470-5
• All: 8 reference(s)